Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15260648 | 0.82 | CYP19A1 (0.49) | PDGFRBKDRAPPCYP19A1FGFR1 | |
| SCHEMBL29177680 | 0.81 | CYP19A1 (0.48) | PDGFRBKDRAPPCYP19A1FGFR1 | |
| SCHEMBL29986368 | 0.81 | CYP19A1 (0.48) | PDGFRBKDRAPPCYP19A1FGFR1 | |
| SCHEMBL27644143 | 0.81 | CYP19A1 (0.48) | PDGFRBKDRAPPCYP19A1FYN | |
| SCHEMBL10213421 | 0.79 | MAPKAPK2 (0.64) | PDGFRBKDRAPPFYNMAPKAPK2 | |
| SCHEMBL1971330 | 0.79 | CYP19A1 (0.47) | PDGFRBKDRAPPCYP19A1FYN | |
| SCHEMBL19133572 | 0.78 | APP (0.57) | APPCYP19A1PIK3CACA1CA2 | |
| SCHEMBL17287941 | 0.78 | CYP19A1 (0.46) | PDGFRBKDRAPPCYP19A1FYN | |
| SCHEMBL17668132 | 0.78 | PDGFRB (0.67) | PDGFRBKDRMKNK1MKNK2 | |
| SCHEMBL398852 | 0.78 | APP (0.58) | APPFYNPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210115029-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2021-04-22 | — | — | US | disclosed |
| US-10669265-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-10633373-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20180111921-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-04-26 | — | — | US | disclosed |
| US-20180111921-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-04-26 | — | — | US | disclosed |
| US-20180105515-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-04-19 | — | — | US | disclosed |
| US-20180105515-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-04-19 | — | — | US | disclosed |
| US-9868726-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2018-01-16 | — | — | US | disclosed |
| US-9868726-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170107210-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2017-04-20 | — | — | US | disclosed |
| US-20170107210-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2017-04-20 | — | — | US | disclosed |
| US-9371314-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-9371314-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-20160102080-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
| US-20160102080-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102080-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | PDGFRB 127/4885KDR 226/4885APP 1526/4885 |
| US-20180105515-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | PDGFRB 127/4885KDR 226/4885APP 1526/4885 |
| US-10633373-B2 | Pyridyl benzothiophenes as kinase inhibitors | PDXK, MAP4K5, MAP4K2 | PDGFRB 127/4885KDR 226/4885APP 1526/4885 |
| US-20180111921-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | PDGFRB 127/4885KDR 226/4885APP 1526/4885 |
| US-20170107210-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | PDGFRB 127/4885KDR 226/4885APP 1526/4885 |
| US-20210115029-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | PDGFRB 127/4885KDR 226/4885APP 1526/4885 |
| US-10669265-B2 | Pyridyl benzothiophenes as kinase inhibitors | PDXK, MAP4K5, MAP4K2 | PDGFRB 127/4885KDR 226/4885APP 1526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.