Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | BAX | Q07812 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17678219 | 0.88 | KMO (0.56) | KMOEGFRP2RX7HTR2AHTR2C | |
| SCHEMBL17673584 | 0.86 | KMO (0.53) | KMOEGFRP2RX7HTR2AHTR2C | |
| SCHEMBL17678119 | 0.85 | EGFR (0.58) | KMOEGFRP2RX7ALOX15MAPK1 | |
| SCHEMBL7804936 | 0.81 | HTR1D (0.50) | KMOP2RX7HTR2AHTR2CHTR2B | |
| SCHEMBL10585036 | 0.81 | NPC1 (0.42) | KMOEGFRBAXTP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL8033639 | 0.80 | HTR1D (0.49) | KMOP2RX7HTR2AHTR2CHTR2B | |
| SCHEMBL17678223 | 0.80 | KMO (0.58) | KMOEGFRMCHR1 | |
| SCHEMBL17673897 | 0.78 | KMO (0.62) | KMOEGFRHTR2AHTR2CHTR2B | |
| SCHEMBL17673722 | 0.77 | EGFR (0.56) | KMOEGFRHTR2AHTR2CHTR2B | |
| SCHEMBL17673896 | 0.77 | KMO (0.56) | KMOEGFRP2RX7HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016057834-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. (US) | 2016-04-14 | — | — | WO | disclosed |