Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17679154 | 0.92 | PCSK9 (0.66) | PCSK9KCNH2 | |
| SCHEMBL17669209 | 0.87 | PCSK9 (0.86) | PCSK9KCNH2 | |
| SCHEMBL17679155 | 0.86 | PCSK9 (0.67) | PCSK9KCNH2 | |
| SCHEMBL17669217 | 0.82 | PCSK9 (0.67) | PCSK9KCNH2 | |
| SCHEMBL17669221 | 0.81 | PCSK9 (0.62) | PCSK9KCNH2 | |
| SCHEMBL17669218 | 0.81 | PCSK9 (0.62) | PCSK9KCNH2 | |
| SCHEMBL17679148 | 0.80 | PCSK9 (0.66) | PCSK9 | |
| SCHEMBL16177062 | 0.79 | PCSK9 (1.00) | PCSK9KCNH2 | |
| SCHEMBL17669169 | 0.79 | PCSK9 (0.86) | PCSK9KCNH2 | |
| SCHEMBL17679153 | 0.78 | PCSK9 (0.65) | PCSK9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055901-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2016-04-14 | — | — | WO | disclosed |
| US-20160102074-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2016-04-14 | — | — | US | disclosed |
| US-20160102074-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102074-A1 | SUBSTITUTED AMIDE COMPOUNDS | CETP, APOB, LCAT | PCSK9 35/4885KCNH2 4672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.