SCHEMBL17679198

SCHEMBL17679198

O=C(Cl)c1ccc2scnc2c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.53
RAB9A P51151 6/20 0.53
KDM4E B2RXH2 1/20 0.53
HKDC1 Q2TB90 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
HSD11B1 P28845 1/20 0.51
NAMPT P43490 1/20 0.51
CRBN Q96SW2 5/20 0.45
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
DDB1 Q16531 3/20 0.43
CLK1 P49759 1/20 0.43
CLK2 P49760 1/20 0.43
CLK3 P49761 1/20 0.43
ESR1 P03372 1/20 0.43
FASN P49327 1/20 0.43
ALDH1A1 P00352 1/20 0.42
HSD17B10 Q99714 1/20 0.42
GFER P55789 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1819290 0.86 NPC1 (0.72) NPC1RAB9AKDM4EHKDC1TDP1
SCHEMBL30917341 0.84 NPC1 (0.74) NPC1RAB9AKDM4EHKDC1TDP1
SCHEMBL261022 0.84 NPC1 (0.74) NPC1RAB9AKDM4EHKDC1TDP1
SCHEMBL4155826 0.82 NPC1 (0.53) NPC1RAB9AKDM4EHKDC1TDP1
SCHEMBL27609695 0.82 NPC1 (0.72) NPC1RAB9AKDM4EHKDC1TDP1
SCHEMBL8861663 0.82 NPC1 (0.53) NPC1RAB9AKDM4EHKDC1TDP1
SCHEMBL27609657 0.82 NPC1 (0.72) NPC1RAB9AKDM4EHKDC1TDP1
SCHEMBL30080720 0.81 NPC1 (0.49) NPC1RAB9AKDM4EHKDC1TDP1
Hydrochloric Acid SCHEMBL6384354 0.81 NPC1 (0.51) NPC1RAB9AKDM4EHKDC1TDP1
SCHEMBL7541632 0.79 NAMPT (0.59) NPC1RAB9AKDM4EHKDC1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4676929-A1 PROTAC DEGRADERS OF MLLT1 AND/OR MLLT3 Dark Blue Therapeutics Ltd (GB) 2026-01-14 EP disclosed
EP-4638447-A1 IMIDAZO[1,2-A]PYRIDINE AND IMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS MLLT1 AND MLLT3 INHIBITORS Dark Blue Therapeutics Ltd (GB) 2025-10-29 EP disclosed
WO-2024188906-A1 PROTAC DEGRADERS OF MLLT1 AND/OR MLLT3 DARK BLUE THERAPEUTICS LTD (GB) 2024-09-19 WO disclosed
EP-4428134-A1 PROTAC DEGRADERS OF MLLT1 AND/OR MLLT3 Dark Blue Therapeutics Ltd (GB) 2024-09-11 EP disclosed
WO-2024133560-A1 IMIDAZO[1,2-A]PYRIDINE AND IMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS MLLT1 AND MLLT3 INHIBITORS DARK BLUE THERAPEUTICS LTD (GB) 2024-06-27 WO disclosed
WO-2024133560-A1 IMIDAZO[1,2-A]PYRIDINE AND IMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS MLLT1 AND MLLT3 INHIBITORS DARK BLUE THERAPEUTICS LTD (GB) 2024-06-27 WO disclosed
EP-4389747-A1 IMIDAZO[1,2-A]PYRIDINE AND IMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS MLLT1 AND MLLT3 INHIBITORS Dark Blue Therapeutics Ltd (GB) 2024-06-26 EP disclosed
CN-107743483-A NADPH oxidase 4 inhibitors 埃科特莱茵药品有限公司 2018-02-27 CN disclosed
WO-2016055607-A1 BENZOTHIAZOLE DERIVATIVE USEFUL IN THE TREATMENT OF CHAGAS DISEASE GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2016-04-14 WO disclosed