Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.73 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31303016 | 0.98 | KIF11 (0.71) | KIF11CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL23666164 | 0.85 | KIF11 (1.00) | KIF11CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL1623940 | 0.85 | KIF11 (1.00) | KIF11CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL4502483 | 0.81 | KIF11 (0.73) | KIF11CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL29468037 | 0.81 | NPC1 (0.68) | KIF11CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL6552315 | 0.81 | NPC1 (0.68) | KIF11CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL22778182 | 0.81 | NPC1 (0.68) | KIF11CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL25390854 | 0.80 | KIF11 (0.78) | KIF11CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL24534338 | 0.79 | CYP2A6 (0.88) | KIF11CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL29360677 | 0.79 | CYP2A6 (0.88) | KIF11CYP2A6CYP3A4ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024258789-A1 | MODULATORS OF CDK2 AND USES THEREOF | TRIANA BIOMEDICINES, INC. (US) | 2024-12-19 | — | — | WO | disclosed |
| US-20170247336-A1 | SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2017-08-31 | — | — | US | disclosed |
| US-20170247336-A1 | SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2017-08-31 | — | — | US | disclosed |
| US-20170247336-A1 | SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2017-08-31 | — | — | US | disclosed |
| WO-2016057762-A1 | SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP (US) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016054804-A1 | SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247336-A1 | SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE | HIF1AN, HIF1A, EGLN2 | KIF11 4607/4885CYP2A6 778/4885CYP3A4 2126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.