Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 7/20 | 0.63 |
| ▸ | BRD4 | O60885 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680981 | 0.88 | CREBBP (0.50) | CREBBPBRD4KMT2ASMYD3GRM5 | |
| SCHEMBL22369200 | 0.84 | CREBBP (0.69) | CREBBPBRD4KMT2AGRM5MEN1 | |
| SCHEMBL17680684 | 0.80 | CREBBP (0.71) | CREBBPBRD4ALDH1A1KDM4ELMNA | |
| SCHEMBL17673284 | 0.77 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL17680595 | 0.77 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL17680681 | 0.77 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL22368804 | 0.76 | CREBBP (0.62) | CREBBPBRD4GRM5ALDH1A1 | |
| SCHEMBL14541030 | 0.70 | CREBBP (0.41) | CREBBPBRD4KMT2AMEN1LMNA | |
| SCHEMBL27060152 | 0.70 | BRD4 (0.39) | CREBBPBRD4KMT2AMEN1KDM4E | |
| SCHEMBL15964658 | 0.69 | CREBBP (0.55) | CREBBPBRD4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |