Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 10/20 | 0.68 |
| ▸ | BRD4 | O60885 | 9/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368638 | 0.89 | CREBBP (0.67) | CREBBPBRD4NPC1RAB9AKMT2A | |
| SCHEMBL17680894 | 0.89 | CREBBP (0.70) | CREBBPBRD4SMN1; SMN2KMT2A | |
| SCHEMBL22368804 | 0.84 | CREBBP (0.62) | CREBBPBRD4GRM5 | |
| SCHEMBL17680804 | 0.81 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL22369208 | 0.80 | CREBBP (0.71) | CREBBPBRD4 | |
| SCHEMBL22368980 | 0.78 | CREBBP (0.76) | CREBBPBRD4 | |
| SCHEMBL22369095 | 0.77 | CREBBP (0.67) | CREBBPBRD4 | |
| SCHEMBL17680618 | 0.72 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL19531743 | 0.72 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL22369200 | 0.71 | CREBBP (0.69) | CREBBPBRD4NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |