Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.66 |
| ▸ | BRD4 | O60885 | 4/20 | 0.66 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680931 | 0.80 | CREBBP (0.62) | CREBBPBRD4EP300BRPF1GAA | |
| SCHEMBL17680929 | 0.80 | CREBBP (0.62) | CREBBPBRD4EP300BRPF1GAA | |
| SCHEMBL17680224 | 0.79 | CREBBP (1.00) | CREBBPBRD4EP300BRPF1 | |
| SCHEMBL4907068 | 0.79 | CREBBP (1.00) | CREBBPBRD4EP300BRPF1 | |
| SCHEMBL549073 | 0.74 | CREBBP (0.59) | CREBBPBRD4GAAMAPTMTNR1A | |
| SCHEMBL22955423 | 0.74 | CREBBP (0.59) | CREBBPBRD4GAAMAPTMTNR1A | |
| SCHEMBL29898373 | 0.71 | CREBBP (0.54) | CREBBPBRD4EP300BRPF1GAA | |
| SCHEMBL29004246 | 0.71 | CREBBP (0.54) | CREBBPBRD4EP300BRPF1GAA | |
| SCHEMBL5805634 | 0.71 | CREBBP (0.54) | CREBBPBRD4EP300BRPF1GAA | |
| SCHEMBL15507913 | 0.71 | CREBBP (0.54) | CREBBPBRD4EP300BRPF1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |
| US-20150147457-A1 | ISOTOPICALLY MODIFIED COMPOUNDS AND THEIR USE AS FOOD SUPPLEMENTS | BIOJIVA LLC | 2015-05-28 | — | — | US | disclosed |