Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 14/20 | 0.65 |
| ▸ | BRD4 | O60885 | 13/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680942 | 1.00 | CREBBP (0.65) | CREBBPBRD4RAB9ANPC1MAPK13 | |
| SCHEMBL17680628 | 0.79 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL17680696 | 0.79 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL17680245 | 0.79 | CREBBP (0.64) | CREBBPBRD4NPC1MAPK13MAPK12 | |
| SCHEMBL22368597 | 0.76 | CREBBP (0.61) | CREBBPBRD4RAB9ANPC1MAPK13 | |
| SCHEMBL22369263 | 0.75 | CREBBP (0.48) | CREBBPBRD4 | |
| SCHEMBL19539030 | 0.75 | CREBBP (0.63) | CREBBPBRD4RAB9AMAPT | |
| SCHEMBL22368600 | 0.73 | CREBBP (0.68) | CREBBPBRD4MAPT | |
| SCHEMBL22369183 | 0.70 | CREBBP (0.65) | CREBBPBRD4RAB9ANPC1MAPK13 | |
| SCHEMBL17680925 | 0.70 | CREBBP (0.65) | CREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |