SCHEMBL22369263

SCHEMBL22369263

C/C=C(\O)c1cccc(/C=C/c2cccc3c2NCCC(=O)N3)c1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 20/20 0.48
BRD4 O60885 16/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22369040 0.87 CREBBP (0.43) CREBBPBRD4
SCHEMBL22368597 0.84 CREBBP (0.61) CREBBPBRD4
SCHEMBL22368888 0.83 CREBBP (0.66) CREBBPBRD4
SCHEMBL17680917 0.81 CREBBP (0.48) CREBBPBRD4
SCHEMBL22368642 0.81 CREBBP (0.48) CREBBPBRD4
SCHEMBL22369015 0.79 CREBBP (0.70) CREBBPBRD4
SCHEMBL17680925 0.78 CREBBP (0.65) CREBBPBRD4
SCHEMBL17680957 0.77 CREBBP (0.65) CREBBPBRD4
SCHEMBL17680954 0.76 CREBBP (0.67) CREBBPBRD4
SCHEMBL22368776 0.76 CREBBP (0.49) CREBBPBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3204360-B1 THERAPEUTIC COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2020-08-26 EP disclosed