Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680890 | 0.87 | TSHR (0.47) | ALDH1A1MAPTMAPK1KDM4EL3MBTL1 | |
| SCHEMBL16401163 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL17673274 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL20916593 | 0.77 | ALDH1A1 (0.55) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL27431445 | 0.77 | ALDH1A1 (0.55) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL8113842 | 0.77 | ALDH1A1 (0.57) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL27477415 | 0.76 | ALDH1A1 (0.56) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL10192631 | 0.75 | ALDH1A1 (0.58) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL11048095 | 0.74 | ALDH1A1 (0.55) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL14192225 | 0.74 | ALDH1A1 (0.50) | ALDH1A1MAPTMAPK1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |