Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 17/20 | 0.65 |
| ▸ | BRD4 | O60885 | 13/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368597 | 0.89 | CREBBP (0.61) | CREBBPBRD4MAPT | |
| SCHEMBL17680954 | 0.86 | CREBBP (0.67) | CREBBPBRD4MAPTSMN1; SMN2 | |
| SCHEMBL17680925 | 0.85 | CREBBP (0.65) | CREBBPBRD4 | |
| SCHEMBL22368776 | 0.85 | CREBBP (0.49) | CREBBPBRD4MAPT | |
| SCHEMBL22369185 | 0.83 | CREBBP (0.67) | CREBBPBRD4 | |
| SCHEMBL17680921 | 0.82 | CREBBP (0.67) | CREBBPBRD4MAPTSMN1; SMN2KDM4E | |
| SCHEMBL22368888 | 0.81 | CREBBP (0.66) | CREBBPBRD4 | |
| SCHEMBL22369183 | 0.80 | CREBBP (0.65) | CREBBPBRD4MAPTKDM4E | |
| SCHEMBL19539030 | 0.80 | CREBBP (0.63) | CREBBPBRD4MAPTSMN1; SMN2KDM4E | |
| SCHEMBL17680835 | 0.79 | CREBBP (1.00) | CREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |