Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 17/20 | 0.49 |
| ▸ | BRD4 | O60885 | 13/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368597 | 0.88 | CREBBP (0.61) | CREBBPBRD4MAPT | |
| SCHEMBL17680925 | 0.87 | CREBBP (0.65) | CREBBPBRD4 | |
| SCHEMBL17680957 | 0.85 | CREBBP (0.65) | CREBBPBRD4MAPT | |
| SCHEMBL22369185 | 0.85 | CREBBP (0.67) | CREBBPBRD4 | |
| SCHEMBL22368624 | 0.84 | CREBBP (0.39) | CREBBPBRD4CYP19A1APPMAPT | |
| SCHEMBL17680921 | 0.84 | CREBBP (0.67) | CREBBPBRD4APPMAPTSNCA | |
| SCHEMBL22368733 | 0.80 | CREBBP (0.69) | CREBBPBRD4MAPT | |
| SCHEMBL22368888 | 0.80 | CREBBP (0.66) | CREBBPBRD4 | |
| SCHEMBL17680954 | 0.80 | CREBBP (0.67) | CREBBPBRD4CYP19A1MAPT | |
| SCHEMBL19539030 | 0.78 | CREBBP (0.63) | CREBBPBRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |