Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 7/20 | 0.74 |
| ▸ | BRD4 | O60885 | 6/20 | 0.47 |
| ▸ | MAOA | P21397 | 6/20 | 0.45 |
| ▸ | MAOB | P27338 | 6/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680752 | 0.85 | CREBBP (1.00) | CREBBPBRD4MAOAMAOB | |
| SCHEMBL4911648 | 0.85 | CREBBP (1.00) | CREBBPBRD4MAOAMAOB | |
| SCHEMBL28923896 | 0.81 | CREBBP (0.67) | CREBBPBRD4MAOAMAOBHRH3 | |
| SCHEMBL31444075 | 0.81 | CREBBP (0.67) | CREBBPBRD4MAOAMAOBHRH3 | |
| SCHEMBL4912276 | 0.79 | CREBBP (0.65) | CREBBPBRD4MAOAMAOBHRH3 | |
| SCHEMBL22368676 | 0.77 | MAOB (0.52) | CREBBPMAOAMAOBHRH3ALOX5 | |
| SCHEMBL26547707 | 0.76 | MAOB (0.55) | CREBBPMAOAMAOBHRH3ALOX5 | |
| SCHEMBL17680931 | 0.73 | CREBBP (0.62) | CREBBPBRD4RAB9A | |
| SCHEMBL17680929 | 0.73 | CREBBP (0.62) | CREBBPBRD4RAB9A | |
| SCHEMBL11515721 | 0.69 | CREBBP (0.53) | CREBBPMAOAMAOBHRH3ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |