Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 12/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 11/20 | 0.37 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17993754 | 0.82 | CA14 (0.40) | HDAC1HDAC2HDAC6CA14KDM4C | |
| SCHEMBL4888113 | 0.82 | HDAC1 (0.44) | HDAC1HDAC2HDAC6LMNACA14 | |
| SCHEMBL2579658 | 0.81 | CA14 (0.53) | HDAC1HDAC2HDAC6LMNACA14 | |
| SCHEMBL1249634 | 0.81 | EPHX2 (0.43) | HDAC1HDAC2HDAC6LMNACA14 | |
| SCHEMBL16713413 | 0.81 | CA14 (0.53) | HDAC1HDAC2HDAC6LMNACA14 | |
| SCHEMBL2194683 | 0.81 | HDAC1 (0.46) | HDAC1HDAC2HDAC6LMNACA14 | |
| SCHEMBL25794000 | 0.80 | CA12 (0.38) | HDAC1HDAC2HDAC6CA14KDM4C | |
| SCHEMBL23113130 | 0.79 | EPHX2 (0.45) | HDAC1HDAC2HDAC6LMNAKDM4C | |
| SCHEMBL28909803 | 0.79 | EPHX2 (0.45) | HDAC1HDAC2HDAC6LMNAKDM4C | |
| Hydrochloric Acid SCHEMBL28881887 | 0.79 | HDAC1 (0.45) | HDAC1HDAC2HDAC6LMNAKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016057413-A2 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2016-04-14 | — | — | WO | disclosed |