SCHEMBL1768484

SCHEMBL1768484

Cc1nc(Cn2nc(-c3nc(CN(C(=O)O)C(C)(C)C)no3)c3ccccc32)cs1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 10/20 0.47
CYP1A2 P05177 6/20 0.47
SCN8A Q9UQD0 2/20 0.47
CYP3A4 P08684 1/20 0.47
SCN1A P35498 1/20 0.39
SCN4A P35499 1/20 0.39
SCN5A Q14524 1/20 0.39
SCN9A Q15858 1/20 0.39
SCN2A Q99250 1/20 0.39
SCN3A Q9NY46 1/20 0.39
SCN10A Q9Y5Y9 1/20 0.39
AURKA O14965 1/20 0.35
AURKB Q96GD4 1/20 0.35
GUCY1A1 Q02108 2/20 0.33
GUCY1B1 Q02153 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1768229 0.84 CYP2D6 (0.55) CYP2D6CYP1A2SCN8ACYP3A4SCN1A
SCHEMBL13583832 0.82 CYP2D6 (0.66) CYP2D6CYP1A2SCN8ACYP3A4SCN1A
SCHEMBL1768236 0.82 CYP2D6 (0.44) CYP2D6CYP1A2SCN8ACYP3A4SCN1A
SCHEMBL1768219 0.81 SCN8A (0.60) CYP2D6CYP1A2SCN8ACYP3A4SCN1A
SCHEMBL12649289 0.80 CYP2D6 (0.71) CYP2D6CYP1A2SCN8ACYP3A4SCN1A
SCHEMBL1768480 0.78 CYP2D6 (0.42) CYP2D6CYP1A2SCN8ACYP3A4SCN1A
SCHEMBL12649291 0.77 CYP2D6 (0.48) CYP2D6CYP1A2SCN8ACYP3A4SCN1A
SCHEMBL1768437 0.77 SCN8A (0.66) CYP2D6CYP1A2SCN8ACYP3A4SCN1A
SCHEMBL1768502 0.71 CYP1A2 (0.48) CYP2D6CYP1A2SCN8ASCN1ASCN4A
SCHEMBL1899543 0.70 CYP2D6 (0.75) CYP2D6CYP1A2SCN8ACYP3A4SCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011061469-A1 INDAZOLE DERIVATIVES AND THEIR USE FOR BLOCKADING VOLTAGE DEPENDENT SODIUM CHANNELS UNIVERSITY COLLEGE LONDON (GB) 2011-05-26 WO disclosed