Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.66 |
| ▸ | SCN1A | P35498 | 2/20 | 0.66 |
| ▸ | SCN4A | P35499 | 2/20 | 0.66 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.66 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.66 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.66 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.66 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768351 | 0.86 | SCN8A (0.55) | SCN8ASCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL11896943 | 0.82 | SCN8A (0.64) | SCN8ASCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL11896942 | 0.82 | SCN8A (0.85) | SCN8ASCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL1768299 | 0.81 | SCN8A (0.69) | SCN8ASCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL12649245 | 0.80 | SCN8A (0.74) | SCN8ASCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL1768467 | 0.80 | SCN8A (1.00) | SCN8ASCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL1768473 | 0.79 | SCN8A (0.85) | SCN8ASCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL1768241 | 0.78 | SCN8A (0.48) | SCN8ASCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL1768434 | 0.78 | SCN8A (0.61) | SCN8ASCN1ASCN4ASCN5ASCN9A | |
| SCHEMBL1768484 | 0.77 | CYP2D6 (0.47) | SCN8ASCN1ASCN4ASCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011061469-A1 | INDAZOLE DERIVATIVES AND THEIR USE FOR BLOCKADING VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2011-05-26 | — | — | WO | disclosed |