Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 18/20 | 0.41 |
| ▸ | TP53 | P04637 | 12/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685053 | 0.91 | MAPT (0.42) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL17685187 | 0.87 | MAPT (0.40) | MAPTTP53THRBLMNA | |
| SCHEMBL2981865 | 0.86 | MAPT (0.42) | MAPTTP53THRBLMNA | |
| SCHEMBL17685211 | 0.84 | MAPT (0.56) | MAPTTP53THRBLMNA | |
| SCHEMBL17685139 | 0.83 | MAPT (0.44) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL17685132 | 0.80 | MAPT (0.35) | MAPTTP53THRBLMNA | |
| SCHEMBL17685152 | 0.80 | SLC6A4 (0.33) | MAPTTP53THRBLMNA | |
| SCHEMBL4153027 | 0.78 | MAPT (0.50) | MAPTTP53THRBLMNASLC2A1 | |
| SCHEMBL17685191 | 0.78 | MAPT (0.46) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL13874914 | 0.78 | MAPT (0.43) | MAPTTP53THRBLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2813498-B1 | Compounds for Alzheimer's disease | MANFREDI JOHN (US) | 2016-04-20 | — | — | EP | claimed |