Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.64 |
| ▸ | SRC | P12931 | 4/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.64 |
| ▸ | PRKCG | P05129 | 3/20 | 0.64 |
| ▸ | PRKCB | P05771 | 3/20 | 0.64 |
| ▸ | PRKCA | P17252 | 3/20 | 0.64 |
| ▸ | PRKCH | P24723 | 3/20 | 0.64 |
| ▸ | PRKCI | P41743 | 3/20 | 0.64 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.64 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.64 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.64 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ABL2 | P42684 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84534 | 0.84 | EGFR (0.62) | EGFRSRCPRKD3PRKCGPRKCB | |
| SCHEMBL30557775 | 0.84 | EGFR (0.62) | EGFRSRCPRKD3PRKCGPRKCB | |
| SCHEMBL133403 | 0.81 | EGFR (0.64) | EGFRSRCPRKD3PRKCGPRKCB | |
| Cgp-53353 SCHEMBL29766901 | 0.78 | EGFR (1.00) | EGFRSRCPRKD3PRKCGPRKCB | |
| Cgp-53353 SCHEMBL230492 | 0.78 | EGFR (1.00) | EGFRSRCPRKD3PRKCGPRKCB | |
| SCHEMBL28772828 | 0.76 | EGFR (0.51) | EGFRSRCPRKD3PRKCGPRKCB | |
| SCHEMBL8834604 | 0.72 | EGFR (0.84) | EGFRSRCPRKD3PRKCGPRKCB | |
| SCHEMBL8834511 | 0.71 | TDO2 (0.45) | PRKCBBRAFPOLB | |
| SCHEMBL8834677 | 0.69 | EGFR (0.77) | EGFRSRCPRKD3PRKCGPRKCB | |
| SCHEMBL8834231 | 0.69 | EGFR (0.77) | EGFRSRCPRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110418851-A | The treatment of cancer and diagnostic method | GENENTECH INC | 2019-11-05 | — | — | CN | disclosed |
| CN-109196121-A | Methods for treatment and diagnosis of cancer | 基因泰克公司 | 2019-01-11 | — | — | CN | disclosed |
| EP-2592156-B1 | Gene expression markers of tumor resistance to HER2 inhibitor treatment | GENENTECH INC (US) | 2016-04-20 | — | — | EP | disclosed |