Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
| ▸ | BTK | Q06187 | 4/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 13/20 | 0.49 |
| ▸ | JAK1 | P23458 | 10/20 | 0.49 |
| ▸ | SYK | P43405 | 5/20 | 0.49 |
| ▸ | ITK | Q08881 | 3/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | PAK4 | O96013 | 2/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | PRKCG | P05129 | 2/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685281 | 0.91 | JAK3 (0.56) | EGFRBTKBRD4JAK3JAK1 | |
| SCHEMBL17685307 | 0.90 | JAK3 (0.59) | EGFRBTKBRD4JAK3JAK1 | |
| SCHEMBL2474134 | 0.88 | EGFR (0.52) | EGFRBTKJAK3JAK1SYK | |
| SCHEMBL4973231 | 0.86 | BRD4 (0.53) | EGFRBTKBRD4JAK3JAK1 | |
| SCHEMBL2471890 | 0.85 | JAK3 (0.63) | EGFRBTKBRD4JAK3JAK1 | |
| SCHEMBL4973352 | 0.81 | SYK (0.58) | EGFRBTKJAK3JAK1SYK | |
| SCHEMBL2470647 | 0.81 | CDK2 (0.53) | EGFRBTKBRD4JAK3JAK1 | |
| SCHEMBL4970836 | 0.81 | EGFR (0.51) | EGFRBTKBRD4JAK3JAK1 | |
| SCHEMBL4973302 | 0.80 | JAK3 (0.52) | EGFRBTKBRD4JAK3JAK1 | |
| SCHEMBL2474786 | 0.79 | JAK3 (0.56) | EGFRBTKJAK3JAK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370415-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2016-04-20 | — | — | EP | claimed |
| EP-2370415-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2016-04-20 | — | — | EP | disclosed |