Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 4/20 | 0.56 |
| ▸ | BTK | Q06187 | 3/20 | 0.56 |
| ▸ | SYK | P43405 | 3/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | ITK | Q08881 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685307 | 0.94 | JAK3 (0.59) | JAK3PTK2EGFRBTKSYK | |
| SCHEMBL17685258 | 0.91 | EGFR (0.51) | JAK3PTK2EGFRBTKSYK | |
| SCHEMBL2471890 | 0.91 | JAK3 (0.63) | JAK3PTK2EGFRBTKSYK | |
| SCHEMBL2470647 | 0.91 | CDK2 (0.53) | JAK3PTK2EGFRBTKSYK | |
| SCHEMBL2474786 | 0.88 | JAK3 (0.56) | JAK3PTK2EGFRBTKSYK | |
| SCHEMBL4971147 | 0.86 | JAK3 (0.56) | JAK3PTK2EGFRBTKSYK | |
| SCHEMBL2475802 | 0.81 | JAK3 (0.60) | JAK3PTK2EGFRBTKSYK | |
| SCHEMBL2475718 | 0.81 | NTRK1 (0.60) | JAK3PTK2EGFRBTKSYK | |
| SCHEMBL4973975 | 0.81 | JAK3 (0.55) | JAK3PTK2EGFRBTKSYK | |
| SCHEMBL2474254 | 0.80 | NTRK1 (0.56) | PTK2NTRK1CDK2AURKACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370415-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2016-04-20 | — | — | EP | claimed |
| EP-2370415-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2016-04-20 | — | — | EP | disclosed |