Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.34 |
| ▸ | JAK3 | P52333 | 9/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.34 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3304622 | 0.94 | JAK2 (0.35) | JAK2JAK3PTK2CDK4CDK6 | |
| SCHEMBL3300972 | 0.80 | GRM4 (0.40) | JAK2JAK3PTK2GRM4KHK | |
| SCHEMBL2145126 | 0.76 | JAK2 (0.39) | JAK2JAK3PTK2GRM4JAK1 | |
| SCHEMBL2145009 | 0.75 | JAK2 (0.39) | JAK2JAK3PTK2GRM4JAK1 | |
| SCHEMBL2144820 | 0.75 | GRM4 (0.39) | JAK2JAK3PTK2GRM4 | |
| SCHEMBL3309539 | 0.75 | GRM4 (0.41) | JAK2JAK3PTK2GRM4 | |
| SCHEMBL2144566 | 0.73 | GRM4 (0.39) | JAK2JAK3PTK2GRM4LRRK2 | |
| SCHEMBL19981194 | 0.73 | JAK2 (0.39) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13391239 | 0.73 | GRM4 (0.40) | JAK2JAK3PTK2GRM4LRRK2 | |
| SCHEMBL2144312 | 0.73 | GRM4 (0.39) | JAK2JAK3PTK2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |