Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685471 | 0.85 | P2RX7 (0.66) | P2RX7KDM4ENPC1 | |
| SCHEMBL306445 | 0.85 | P2RX7 (0.49) | P2RX7BACE1KDM4E | |
| SCHEMBL17685464 | 0.82 | P2RX7 (0.50) | P2RX7KDM4ENPC1 | |
| SCHEMBL307176 | 0.79 | P2RX7 (0.55) | P2RX7 | |
| SCHEMBL306523 | 0.79 | P2RX7 (0.74) | P2RX7KDM4E | |
| SCHEMBL27776446 | 0.74 | P2RX7 (0.66) | P2RX7KDM4E | |
| SCHEMBL306906 | 0.74 | P2RX7 (0.66) | P2RX7KDM4E | |
| SCHEMBL307383 | 0.70 | P2RX7 (0.69) | P2RX7 | |
| SCHEMBL17690541 | 0.70 | P2RX7 (0.61) | P2RX7 | |
| SCHEMBL14407705 | 0.69 | P2RX7 (0.76) | P2RX7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124562-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-04-20 | — | — | EP | claimed |