SCHEMBL17688554

SCHEMBL17688554

COC(=O)/C=C/C(=O)NC(C)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 3/20 0.52
KEAP1 Q14145 1/20 0.52
NFE2L2 Q16236 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.51
GFPT1 Q06210 1/20 0.50
ALDH1A1 P00352 4/20 0.45
GAA P10253 1/20 0.45
CA2 P00918 2/20 0.42
KDM4E B2RXH2 2/20 0.38
LMNA P02545 2/20 0.38
HTT P42858 1/20 0.38
MAPT P10636 2/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALOX15 P16050 1/20 0.34
RECQL P46063 1/20 0.34
HSD17B10 Q99714 1/20 0.34
RAB9A P51151 1/20 0.34
MME P08473 1/20 0.34
ACE P12821 1/20 0.34
CPA1 P15085 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17688555 1.00 HCAR2 (0.52) HCAR2KEAP1NFE2L2SMN1; SMN2GFPT1
SCHEMBL11222703 0.81 ALDH1A1 (0.68) HCAR2SMN1; SMN2ALDH1A1GAAHTT
SCHEMBL4572574 0.81 ALDH1A1 (0.68) HCAR2SMN1; SMN2ALDH1A1GAAHTT
SCHEMBL4572573 0.81 ALDH1A1 (0.68) HCAR2SMN1; SMN2ALDH1A1GAAHTT
SCHEMBL10935338 0.81 ALDH1A1 (0.68) HCAR2SMN1; SMN2ALDH1A1GAAHTT
SCHEMBL10442657 0.81 HCAR2 (0.48) HCAR2KEAP1NFE2L2SMN1; SMN2GFPT1
SCHEMBL9304164 0.77 SMN1; SMN2 (0.47) SMN1; SMN2ALDH1A1GAAMAPTTDP1
SCHEMBL9304160 0.77 SMN1; SMN2 (0.47) SMN1; SMN2ALDH1A1GAAMAPTTDP1
SCHEMBL9304167 0.77 SMN1; SMN2 (0.47) SMN1; SMN2ALDH1A1GAAMAPTTDP1
SCHEMBL23671815 0.77 ALDH1A1 (0.53) HCAR2KEAP1NFE2L2GFPT1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016061393-A1 FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE XENOPORT, INC. (US) 2016-04-21 WO claimed
WO-2016061393-A1 FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE XENOPORT, INC. (US) 2016-04-21 WO disclosed
WO-2016061393-A1 FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE XENOPORT, INC. (US) 2016-04-21 WO disclosed