Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 5/20 | 0.40 |
| ▸ | EDNRA | P25101 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | IL2 | P60568 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17689125 | 0.84 | EDNRA (0.39) | EDNRBEDNRABRD4LTA4HACLY | |
| SCHEMBL18230068 | 0.81 | PIK3CD (0.40) | EDNRBEDNRABRD4IL2LTA4H | |
| SCHEMBL18229961 | 0.81 | BRD4 (0.38) | EDNRBEDNRABRD4LTA4HPIK3CD | |
| SCHEMBL18930006 | 0.79 | NPC1 (0.46) | BRD4IL2LTA4HP2RX7HPGDS | |
| SCHEMBL8591966 | 0.76 | LTA4H (0.47) | EDNRBEDNRALTA4HHPGDS | |
| SCHEMBL4764672 | 0.74 | LTA4H (0.42) | EDNRBEDNRABRD4IL2LTA4H | |
| SCHEMBL10317579 | 0.74 | NPC1 (0.51) | BRD4IL2LTA4HP2RX7HPGDS | |
| SCHEMBL377220 | 0.74 | IL2 (0.46) | BRD4IL2LTA4HP2RX7HPGDS | |
| SCHEMBL6499200 | 0.74 | NPC1 (0.50) | BRD4IL2LTA4HP2RX7HPGDS | |
| SCHEMBL1459892 | 0.74 | NPC1 (0.44) | BRD4IL2LTA4HP2RX7HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922841-B1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | disclosed |
| US-9315494-B2 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-19 | — | — | US | disclosed |