Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27766668 | 0.84 | MAPT (0.47) | PDE2APTGS2HTR2ASLC6A4KCNH2 | |
| SCHEMBL12401761 | 0.82 | CYP2C19 (0.40) | NR1H3PTGS2PTGS1KCNH2MAPT | |
| SCHEMBL170653 | 0.79 | ESR1 (0.49) | PDE2AMAPTCYP2D6GAAIDH2 | |
| SCHEMBL8346846 | 0.79 | PDK2 (0.51) | PDE2APDK2NR1H3MRGPRX4MAPT | |
| SCHEMBL11544632 | 0.78 | ALDH1A1 (0.46) | PDE2APDK2NR1H3MAPTALDH1A1 | |
| SCHEMBL18160746 | 0.78 | IDH2 (0.38) | PDE2ACYP2D6GAAIDH2KMT2A | |
| SCHEMBL17993800 | 0.76 | ALDH1A1 (0.37) | PDE2ASLC6A4MAPTALDH1A1CYP2D6 | |
| SCHEMBL2968966 | 0.76 | GAA (0.50) | SLC6A4MAPTALDH1A1GAALMNA | |
| SCHEMBL5108912 | 0.76 | KDM4E (0.44) | PDE2APDK2NR1H3MRGPRX4MAPT | |
| SCHEMBL13696457 | 0.73 | KDM1A (0.40) | PDE2AMAPTCYP2D6GAAIDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111039792-B | Preparation method of aniline compound | 苏州开元民生科技股份有限公司 | 2022-10-14 | — | — | CN | claimed |
| CN-117777024-A | Improved process for preparing arylpyrazole nitriles | 江苏优普生物化学科技股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-111039792-B | Preparation method of aniline compound | 苏州开元民生科技股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-111039792-B | Preparation method of aniline compound | 苏州开元民生科技股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-216321856-U | Device for recovering dimethylamine in process of synthesizing fipronil | 山东海利尔化工有限公司 | 2022-04-19 | — | — | CN | disclosed |
| CN-110845340-B | Preparation method of fipronil intermediate | 苏州开元民生科技股份有限公司 | 2022-03-22 | — | — | CN | disclosed |
| WO-2011058577-A1 | PROCESS FOR SYNTHESIZING POLYHALOGENATED PERHALOALKYLANILINE COMPOUNDS | GHARDA KEKI HORMUSJI (IN) | 2011-05-19 | — | — | WO | disclosed |
| CN-1436769-A | Prepn process of 2,6-dichloro-4-trifluoro methylaniline | SHANGHAI TIANHAO MEDICINE SCI (CN) | 2003-08-20 | — | — | CN | disclosed |
| US-5616810-A | DEALKYLATION BY REACTING AN N-ALKYL OF N,N-DIALKYL ANILINE WITH AMMONIA OR A PRIMARY OR SECONDARY AMINE USING A PYRIDINE SALT CATALYST | RHONE-POULENC CHIMIE (FR) | 1997-04-01 | — | — | US | disclosed |
| US-5401882-A | Reaction of halobenzenes with dialkyl amide to form dialkyl anilines, dealkylation | RHONE-POULENC CHIMIE (FR) | 1995-03-28 | — | — | US | disclosed |