Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.78 |
| ▸ | EML4 | Q9HC35 | 15/20 | 0.78 |
| ▸ | FLT3 | P36888 | 10/20 | 0.59 |
| ▸ | RET | P07949 | 9/20 | 0.59 |
| ▸ | ROS1 | P08922 | 9/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | BUB1 | O43683 | 1/20 | 0.50 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.50 |
| ▸ | STK16 | O75716 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | LATS1 | O95835 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | SLC25A5 | P05141 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129248 | 0.94 | ALK (0.85) | ALKEML4FLT3RETROS1 | |
| SCHEMBL282103 | 0.87 | EML4 (1.00) | ALKEML4FLT3RETROS1 | |
| SCHEMBL282104 | 0.87 | EML4 (1.00) | ALKEML4FLT3RETROS1 | |
| SCHEMBL10129301 | 0.85 | ALK (0.84) | ALKEML4FLT3RETROS1 | |
| SCHEMBL10129226 | 0.84 | EML4 (0.88) | ALKEML4FLT3RETROS1 | |
| SCHEMBL10126754 | 0.81 | ALK (0.65) | ALKEML4FLT3RETROS1 | |
| SCHEMBL10129265 | 0.80 | EML4 (0.85) | ALKEML4FLT3RETROS1 | |
| SCHEMBL10129244 | 0.79 | EML4 (0.84) | ALKEML4FLT3RETROS1 | |
| SCHEMBL10129242 | 0.79 | EML4 (0.84) | ALKEML4FLT3RETROS1 | |
| SCHEMBL10129419 | 0.79 | EML4 (0.80) | ALKEML4FLT3RETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009428-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |