Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 8/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | AXL | P30530 | 3/20 | 0.36 |
| ▸ | ETV6 | P41212 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27865329 | 0.85 | EML4 (0.44) | EML4ALKEGFRSYKAXL | |
| SCHEMBL328322 | 0.84 | PRKCQ (0.48) | EML4ALKEGFRSYK | |
| SCHEMBL25808819 | 0.81 | SYK (0.47) | EML4ALKEGFRSYKRET | |
| SCHEMBL30300923 | 0.81 | SYK (0.47) | EML4ALKEGFRSYKRET | |
| SCHEMBL283230 | 0.81 | EML4 (0.66) | EML4ALKSYKMEN1KMT2A | |
| SCHEMBL328224 | 0.79 | EML4 (0.41) | EML4ALKSYKRETROS1 | |
| SCHEMBL10127324 | 0.78 | EML4 (0.39) | EML4ALKEGFRSYKAXL | |
| SCHEMBL10127274 | 0.78 | MAPKAPK2 (0.43) | EML4ALKMEN1KMT2A | |
| SCHEMBL26690230 | 0.78 | EML4 (0.42) | EML4ALKSYKMEN1KMT2A | |
| SCHEMBL10127286 | 0.77 | MAPT (0.45) | EML4ALKEGFRSYKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009428-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |