Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.64 |
| ▸ | EML4 | Q9HC35 | 15/20 | 0.64 |
| ▸ | RET | P07949 | 12/20 | 0.64 |
| ▸ | ROS1 | P08922 | 12/20 | 0.64 |
| ▸ | FLT3 | P36888 | 12/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129736 | 0.91 | ALK (0.78) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10129732 | 0.84 | ALK (0.76) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10129456 | 0.83 | ALK (0.80) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10129478 | 0.81 | ALK (0.88) | ALKEML4RETROS1FLT3 | |
| SCHEMBL16206859 | 0.79 | EML4 (0.75) | ALKEML4RETROS1FLT3 | |
| SCHEMBL16206864 | 0.79 | EML4 (0.75) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10129542 | 0.79 | ALK (0.66) | ALKEML4RETROS1FLT3 | |
| SCHEMBL282486 | 0.78 | EML4 (1.00) | ALKEML4RETROS1FLT3 | |
| SCHEMBL282487 | 0.78 | EML4 (1.00) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10129740 | 0.77 | ALK (0.80) | ALKEML4RETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009428-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |