Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12986681 | 1.00 | HSD17B10 (0.40) | HSD17B10NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL770405 | 1.00 | HSD17B10 (0.40) | HSD17B10NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL771735 | 0.84 | NPC1 (0.40) | NPC1POLBRAB9ASMN1; SMN2TDP1 | |
| SCHEMBL12985587 | 0.82 | ALDH1A1 (0.41) | NPC1POLBRAB9ASMN1; SMN2TDP1 | |
| SCHEMBL769908 | 0.82 | ALDH1A1 (0.41) | NPC1POLBRAB9ASMN1; SMN2TDP1 | |
| SCHEMBL770763 | 0.80 | NPC1 (0.53) | NPC1POLBRAB9ASMN1; SMN2TDP1 | |
| SCHEMBL771126 | 0.80 | NPC1 (0.41) | NPC1POLBALDH1A1L3MBTL1HPGD | |
| SCHEMBL12984520 | 0.80 | NPC1 (0.41) | NPC1POLBALDH1A1L3MBTL1HPGD | |
| SCHEMBL770536 | 0.78 | NPC1 (0.45) | NPC1POLBRAB9ASMN1; SMN2TDP1 | |
| SCHEMBL771477 | 0.77 | HSD11B1 (0.44) | HSD17B10NPC1POLBRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2439202-B1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | SALVAT LAB SA (ES) | 2016-04-20 | — | — | EP | disclosed |