Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.49 |
| ▸ | SKP1 | P63208 | 2/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.49 |
| ▸ | GALR2 | O43603 | 1/20 | 0.43 |
| ▸ | GALR1 | P47211 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14413677 | 0.90 | CKS1B (0.48) | CKS1BSKP1SKP2GALR2GALR1 | |
| SCHEMBL14413660 | 0.85 | CKS1B (0.45) | CKS1BSKP1SKP2GALR2GALR1 | |
| SCHEMBL14050908 | 0.80 | TYK2 (0.39) | CKS1BSKP1SKP2GALR2GALR1 | |
| SCHEMBL14050806 | 0.76 | JAK3 (0.38) | CKS1BSKP1SKP2GALR2GALR1 | |
| SCHEMBL14051003 | 0.74 | CKS1B (0.49) | CKS1BSKP1SKP2GALR2GALR1 | |
| SCHEMBL20533951 | 0.72 | HPGD (0.40) | CKS1BSKP1SKP2MAPTMEN1 | |
| SCHEMBL24851168 | 0.72 | CKS1B (0.53) | CKS1BSKP1SKP2GALR2GALR1 | |
| SCHEMBL14413674 | 0.72 | CKS1B (0.51) | CKS1BSKP1SKP2CDK2PDE10A | |
| SCHEMBL1934892 | 0.72 | CSNK2B (0.51) | CKS1BSKP1SKP2MAPTMAP4K4 | |
| SCHEMBL24851476 | 0.72 | CKS1B (0.55) | CKS1BSKP1SKP2GALR2GALR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931677-B1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-04-20 | — | — | EP | disclosed |