Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 6/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050865 | 0.89 | PDE10A (0.43) | PDE10ACKS1BSKP1SKP2JAK3 | |
| SCHEMBL11930799 | 0.79 | PDE10A (0.36) | PDE10ACKS1BSKP1SKP2JAK3 | |
| SCHEMBL14050804 | 0.79 | SUV39H2 (0.43) | PDE10ACKS1BSKP1SKP2JAK3 | |
| SCHEMBL14050800 | 0.78 | PDE10A (0.47) | PDE10ACKS1BSKP1SKP2JAK3 | |
| SCHEMBL11931288 | 0.78 | PDE10A (0.42) | PDE10ACKS1BSKP1SKP2JAK3 | |
| SCHEMBL11931289 | 0.74 | PDE10A (0.44) | PDE10ACKS1BSKP1SKP2JAK3 | |
| SCHEMBL14050871 | 0.72 | NPC1 (0.40) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL26180093 | 0.72 | PDE10A (0.50) | PDE10ACKS1BSKP1SKP2JAK3 | |
| SCHEMBL11931287 | 0.71 | CKS1B (0.49) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL14050907 | 0.70 | SUV39H2 (0.40) | PDE10ACKS1BSKP1SKP2SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931677-B1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-04-20 | — | — | EP | disclosed |