SCHEMBL17697886

SCHEMBL17697886

COc1cc2c(N)nc(N3CCN(C(=O)CC(N)c4ccccc4)CC3)nc2c(Br)c1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CFD P00746 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16689372 1.00 CFD (1.00) CFD
SCHEMBL16689361 0.91 CFD (1.00) CFD
SCHEMBL16680111 0.91 CFD (1.00) CFD
SCHEMBL17697924 0.89 CFD (1.00) CFD
SCHEMBL16689368 0.89 CFD (1.00) CFD
SCHEMBL17697928 0.86 CFD (1.00) CFD
SCHEMBL16689356 0.86 CFD (1.00) CFD
Hydrochloric Acid SCHEMBL16681221 0.85 CFD (0.98) CFD
Hydrochloric Acid SCHEMBL16681218 0.85 CFD (0.98) CFD
SCHEMBL16680766 0.85 CFD (1.00) CFD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2864322-B1 COMPLEMENT PATHWAY MODULATORS AND USES THEREOF NOVARTIS AG (CH) 2016-04-27 EP claimed
EP-2864322-B1 COMPLEMENT PATHWAY MODULATORS AND USES THEREOF NOVARTIS AG (CH) 2016-04-27 EP disclosed