Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17482288 | 0.82 | SMN1; SMN2 (0.58) | NPC1HTTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL10202979 | 0.81 | RAB9A (0.57) | NPC1HTTRAB9ASMN1; SMN2ATM | |
| SCHEMBL12895756 | 0.78 | SMN1; SMN2 (0.57) | NPC1HTTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL15471161 | 0.76 | RAB9A (0.63) | NPC1HTTRAB9ASMN1; SMN2NOTUM | |
| SCHEMBL12868306 | 0.75 | NOTUM (0.45) | NPC1HTTRAB9ASMN1; SMN2NOTUM | |
| SCHEMBL10202910 | 0.71 | SMN1; SMN2 (0.56) | NPC1HTTRAB9ASMN1; SMN2NOTUM | |
| SCHEMBL28713775 | 0.71 | RAB9A (0.56) | NPC1HTTRAB9ASMN1; SMN2NOTUM | |
| SCHEMBL12759453 | 0.71 | RAB9A (0.49) | NPC1HTTRAB9ASMN1; SMN2CASP3 | |
| SCHEMBL95288 | 0.70 | NOTUM (0.50) | HTTNOTUMATMNPSR1KDM4E | |
| SCHEMBL15379098 | 0.69 | RAB9A (0.54) | NPC1HTTRAB9ASMN1; SMN2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9321731-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-04-26 | — | — | US | disclosed |