Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP7 | P09237 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL320398 | 1.00 | PHGDH (0.43) | PHGDHMMP1MMP2MMP3MMP7 | |
| SCHEMBL319951 | 0.84 | HTT (0.44) | PHGDHMMP2MMP3KDM4EGAA | |
| SCHEMBL27904556 | 0.84 | HTT (0.44) | PHGDHMMP2MMP3KDM4EGAA | |
| SCHEMBL320114 | 0.84 | HTT (0.44) | PHGDHMMP2MMP3KDM4EGAA | |
| SCHEMBL320148 | 0.84 | HTT (0.44) | PHGDHMMP2MMP3KDM4EGAA | |
| SCHEMBL320377 | 0.84 | HTT (0.44) | PHGDHMMP2MMP3KDM4EGAA | |
| SCHEMBL12505583 | 0.81 | CTSK (0.46) | PHGDHMMP1MMP2MMP3MMP7 | |
| SCHEMBL321244 | 0.81 | CTSK (0.46) | PHGDHMMP1MMP2MMP3MMP7 | |
| SCHEMBL3124464 | 0.79 | PHGDH (0.51) | PHGDHKDM4EGAAMAPTL3MBTL1 | |
| SCHEMBL12505582 | 0.79 | PHGDH (0.51) | PHGDHKDM4EGAAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590956-B1 | 5-(biphenyl-4-yl)-3-phenyl-1,2,4-oxadiazolyl derivatives as ligands on the sphingosine 1-phosphate (S1P) receptors | MERCK SERONO SA (CH) | 2016-05-04 | — | — | EP | disclosed |