Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.43 |
| ▸ | HTR2B | P41595 | 9/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3079478 | 0.84 | SLC6A2 (0.49) | HTR2CHTR2BMAP2K1SLC6A4SLC6A2 | |
| SCHEMBL15337538 | 0.84 | HTR2C (0.43) | HTR2CHTR2BMAP2K1SLC6A4SLC6A2 | |
| SCHEMBL18066866 | 0.83 | CSNK2A1 (0.39) | HTR2CHTR2BMAP2K1RORCSLC6A4 | |
| SCHEMBL17708042 | 0.83 | CYP2C19 (0.41) | HTR2CHTR2BMAP2K1RORCSLC6A4 | |
| SCHEMBL5369456 | 0.77 | HTR2C (0.51) | HTR2CHTR2BRORCSLC6A4 | |
| SCHEMBL15372308 | 0.75 | HTR2C (0.53) | HTR2CHTR2BMAP2K1SLC6A4HTR2A | |
| SCHEMBL19527715 | 0.74 | SLC6A2 (0.47) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11245188 | 0.73 | SLC6A2 (0.54) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11245201 | 0.73 | SLC6A2 (0.54) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11245194 | 0.73 | SLC6A2 (0.54) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-9321763-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2016-04-26 | — | — | US | disclosed |