Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | KCNN4 | O15554 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18066884 | 0.84 | LRRK2 (0.39) | LRRK2KCNN4ALDH1A1NOTUML3MBTL1 | |
| SCHEMBL17708101 | 0.84 | LRRK2 (0.41) | LRRK2KCNN4ALDH1A1NOTUM | |
| SCHEMBL19836365 | 0.78 | LRRK2 (0.40) | LRRK2KCNN4ALDH1A1NOTUM | |
| SCHEMBL15651468 | 0.78 | LRRK2 (0.47) | LRRK2KCNN4ALDH1A1NOTUML3MBTL1 | |
| SCHEMBL15337425 | 0.77 | ALDH1A1 (0.36) | LRRK2KCNN4ALDH1A1NOTUMKMT2A | |
| SCHEMBL15337423 | 0.77 | NOTUM (0.40) | LRRK2KCNN4ALDH1A1NOTUMMEN1 | |
| SCHEMBL15786417 | 0.73 | KMT2A (0.55) | KCNN4ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL18066891 | 0.73 | USP2 (0.38) | LRRK2KCNN4ALDH1A1KMT2ALMNA | |
| SCHEMBL18066921 | 0.73 | TACR1 (0.42) | KCNN4ALDH1A1NOTUML3MBTL1MEN1 | |
| SCHEMBL17708099 | 0.73 | CA1 (0.38) | LRRK2KCNN4ALDH1A1NOTUMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-9321763-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2016-04-26 | — | — | US | disclosed |