Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MELK | Q14680 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31532636 | 1.00 | USP30 (0.59) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532675 | 1.00 | USP30 (0.59) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532647 | 0.97 | USP30 (0.56) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532519 | 0.97 | USP30 (0.56) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532558 | 0.95 | USP30 (0.54) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532646 | 0.95 | USP30 (0.54) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532597 | 0.92 | USP30 (0.52) | USP30HDAC4HDAC6PARP1BTK | |
| SCHEMBL31532630 | 0.92 | USP30 (0.52) | USP30HDAC4HDAC6PARP1BTK | |
| SCHEMBL31532654 | 0.90 | USP30 (0.59) | USP30HDAC4HDAC6PARP1BTK | |
| SCHEMBL31532587 | 0.90 | USP30 (0.59) | USP30HDAC4HDAC6PARP1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112144-A1 | METHODS OF PREPARING SUBSTITUTED HETEROCYCLES | ASTRAZENECA AB (SE) | 2011-05-12 | — | — | US | disclosed |
| US-20110112144-A1 | METHODS OF PREPARING SUBSTITUTED HETEROCYCLES | ASTRAZENECA AB (SE) | 2011-05-12 | — | — | US | disclosed |
| WO-2009133389-A1 | METHODS OF PREPARING SUBSTITUTED HETEROCYCLES | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112144-A1 | METHODS OF PREPARING SUBSTITUTED HETEROCYCLES | HCCS, DPYD, TYMP | USP30 3122/4885HDAC4 2607/4885HDAC6 2729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.