Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MELK | Q14680 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31532636 | 1.00 | USP30 (0.59) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL1770908 | 1.00 | USP30 (0.59) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532647 | 0.97 | USP30 (0.56) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532519 | 0.97 | USP30 (0.56) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532558 | 0.95 | USP30 (0.54) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532646 | 0.95 | USP30 (0.54) | USP30HDAC4HDAC6PARP1MELK | |
| SCHEMBL31532597 | 0.92 | USP30 (0.52) | USP30HDAC4HDAC6PARP1BTK | |
| SCHEMBL31532630 | 0.92 | USP30 (0.52) | USP30HDAC4HDAC6PARP1BTK | |
| SCHEMBL31532654 | 0.90 | USP30 (0.59) | USP30HDAC4HDAC6PARP1BTK | |
| SCHEMBL31532587 | 0.90 | USP30 (0.59) | USP30HDAC4HDAC6PARP1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025099238-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF GASTROINTESTINAL STROMAL TUMOR (GIST) | Universität Duisburg-Essen (DE) | 2025-05-15 | — | — | WO | disclosed |
| EP-4552639-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF GASTROINTESTINAL STROMAL TUMOR (GIST) | Universität Duisburg-Essen (DE) | 2025-05-14 | — | — | EP | disclosed |