⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15936903 | 0.86 | LMNA (0.33) | — | |
| SCHEMBL17712370 | 0.86 | LMNA (0.33) | — | |
| SCHEMBL20804207 | 0.86 | LMNA (0.33) | — | |
| SCHEMBL18121975 | 0.79 | — | — | |
| SCHEMBL18558855 | 0.78 | GRIN2B (0.35) | — | |
| SCHEMBL17716626 | 0.75 | PDE7B (0.31) | — | |
| SCHEMBL17712383 | 0.75 | PDE7B (0.31) | — | |
| SCHEMBL21466062 | 0.75 | — | — | |
| SCHEMBL13059971 | 0.75 | SLC6A2 (0.33) | — | |
| SCHEMBL19852922 | 0.74 | LMNA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170231956-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2017-08-17 | — | — | US | disclosed |
| US-9579304-B2 | Spiro-lactam NMDA receptor modulators and uses thereof | Aptinyx, Inc. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160368926-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | Aptinyx Incorporated (US) | 2016-12-22 | — | — | US | disclosed |
| US-9512134-B2 | Spiro-lactam NMDA receptor modulators and uses thereof | Aptinyx, Inc. (US) | 2016-12-06 | — | — | US | disclosed |
| US-9512134-B2 | Spiro-lactam NMDA receptor modulators and uses thereof | Aptinyx, Inc. (US) | 2016-12-06 | — | — | US | disclosed |
| US-9504670-B2 | Spiro-lactam NMDA receptor modulators and uses thereof | Aptinyx, Inc. (US) | 2016-11-29 | — | — | US | disclosed |
| US-20160289240-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2016-10-06 | — | — | US | disclosed |
| US-20160289240-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2016-10-06 | — | — | US | disclosed |
| US-20160122359-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2016-05-05 | — | — | US | disclosed |
| US-20160122359-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2016-05-05 | — | — | US | disclosed |