SCHEMBL17718804

SCHEMBL17718804

Clc1ccc(-c2nc3ccccn3c2CN2CCOCC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ SLC2A1 P11166 17/20 1.00
▸ KDM4E B2RXH2 4/20 1.00
▸ GAA P10253 1/20 1.00
▸ HTT P42858 1/20 0.74
▸ SLC2A3 P11169 1/20 0.66
▸ SLC2A4 P14672 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28620843 0.90 SLC2A1 (0.82) SLC2A1KDM4EGAAHTT
SCHEMBL18963146 0.86 KDM4E (0.78) SLC2A1KDM4EGAAHTT
SCHEMBL17718902 0.85 SLC2A1 (0.74) SLC2A1KDM4EGAAHTTSLC2A3
SCHEMBL17718817 0.85 SLC2A1 (1.00) SLC2A1KDM4EGAAHTTSLC2A3
SCHEMBL16246716 0.85 SLC2A1 (1.00) SLC2A1KDM4EHTTSLC2A3SLC2A4
Hydrochloric Acid SCHEMBL18952318 0.85 KDM4E (0.77) SLC2A1KDM4EGAAHTT
SCHEMBL30398431 0.84 KDM4E (0.75) SLC2A1KDM4EGAAHTT
SCHEMBL18963197 0.84 KDM4E (0.75) SLC2A1KDM4EGAA
SCHEMBL17718885 0.82 SLC2A1 (0.79) SLC2A1KDM4EGAAHTTSLC2A3
SCHEMBL22364213 0.82 KCNK3 (0.76) SLC2A1KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 — — US disclosed
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS SLCO1A2, SLCO2B1, SLCO2A1 SLC2A1 6/4885KDM4E 4043/4885GAA 1005/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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