SCHEMBL17719159

SCHEMBL17719159

CC(C)(C)OC(=O)N1CCN(C(=O)c2c(-c3ccc(Cl)cc3)nc3ccc(-c4ccccc4)cn23)CC1

nearest known ligand 0.59

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ SLC2A1 P11166 11/20 0.56
▸ ALOX5 P09917 1/20 0.51
▸ TOP2A P11388 1/20 0.50
▸ SLC2A2 P11168 2/20 0.49
▸ KCNK3 O14649 1/20 0.49
▸ KCNK9 Q9NPC2 1/20 0.49
▸ CYP1A2 P05177 1/20 0.48
▸ CYP2C9 P11712 1/20 0.48
▸ CYP2C19 P33261 1/20 0.48
▸ MEN1 O00255 1/20 0.48
▸ KMT2A Q03164 1/20 0.48
▸ CKS1B P61024 1/20 0.48
▸ SKP1 P63208 1/20 0.48
▸ SKP2 Q13309 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17719050 0.87 SLC2A1 (0.51) SLC2A1TOP2ASLC2A2CYP1A2CYP2C9
SCHEMBL17719043 0.86 SLC2A1 (0.61) SLC2A1SLC2A2CYP1A2CYP2C9CYP2C19
SCHEMBL16246753 0.84 SLC2A1 (0.76) SLC2A1KCNK3KCNK9
SCHEMBL17719051 0.82 SLC2A1 (0.61) SLC2A1SLC2A2
SCHEMBL17719042 0.82 SLC2A2 (0.70) SLC2A1SLC2A2
SCHEMBL5318501 0.79 MEN1 (0.58) SLC2A1ALOX5KCNK3KCNK9MEN1
SCHEMBL17719163 0.74 SLC2A1 (0.52) SLC2A1SLC2A2KCNK3KCNK9
SCHEMBL18963196 0.74 KCNK3 (0.79) KCNK3KCNK9
SCHEMBL17718924 0.73 SLC2A1 (0.73) SLC2A1SLC2A2
SCHEMBL4920109 0.72 FASN (0.66) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 — — US disclosed
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS SLCO1A2, SLCO2B1, SLCO2A1 SLC2A1 6/4885ALOX5 3680/4885TOP2A 898/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback