Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21105599 | 0.78 | NR1I2 (0.40) | PDE1APDE1BPDE1C | |
| Hydrochloric Acid SCHEMBL21067209 | 0.77 | NR1I2 (0.39) | PDE1APDE1BPDE1C | |
| SCHEMBL4866590 | 0.72 | DHFR (0.44) | — | |
| SCHEMBL21067154 | 0.72 | PDE1A (0.33) | PDE1APDE1BPDE1C | |
| SCHEMBL6269053 | 0.71 | NR1I2 (0.40) | PDE1APDE1BPDE1CGABRA1GABRB2 | |
| SCHEMBL2789584 | 0.70 | KDM4E (0.34) | — | |
| SCHEMBL26901801 | 0.70 | TSHR (0.41) | PDE1APDE1BPDE1C | |
| SCHEMBL20696788 | 0.69 | TOP2A (0.36) | PDE1APDE1BPDE1CGABRA1 | |
| SCHEMBL25468685 | 0.68 | PDE1A (0.32) | PDE1APDE1BPDE1C | |
| SCHEMBL21258479 | 0.67 | TOP2A (0.34) | PDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611805-A1 | FUSED TRIAZOLES FOR THE TREATMENT OR PROPHYLAXIS OF MILD COGNITIVE IMPAIRMENT | Takeda Pharmaceutical Company Limited (JP) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029991-A1 | FUSED TRIAZOLES FOR THE TREATMENT OR PROPHYLAXIS OF MILD COGNITIVE IMPAIRMENT | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-08 | — | — | WO | disclosed |