Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 11/20 | 0.57 |
| ▸ | DCLK1 | O15075 | 10/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.55 |
| ▸ | PIK3C2G | O75747 | 3/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.55 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.46 |
| ▸ | DCLK2 | Q8N568 | 1/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19496544 | 0.85 | MAPK7 (0.52) | MAPK7DCLK1LRRK2PIK3CDAURKA | |
| SCHEMBL10098691 | 0.84 | MAPK7 (0.56) | MAPK7DCLK1LRRK2PIK3CDAURKA | |
| SCHEMBL10098766 | 0.84 | DCLK1 (0.58) | MAPK7DCLK1LRRK2PIK3CDAURKA | |
| SCHEMBL22663660 | 0.83 | PIK3CD (0.58) | MAPK7LRRK2PIK3CDAURKAPIK3C2G | |
| SCHEMBL17519893 | 0.79 | DCLK1 (0.78) | MAPK7DCLK1LRRK2PIK3CDAURKA | |
| SCHEMBL17854805 | 0.78 | MAPK7 (0.53) | MAPK7DCLK1LRRK2PIK3CDAURKA | |
| SCHEMBL19496540 | 0.78 | MAPK7 (0.49) | MAPK7DCLK1LRRK2PIK3CDAURKA | |
| SCHEMBL29531391 | 0.78 | MAPK7 (0.49) | MAPK7DCLK1LRRK2PIK3CDAURKA | |
| SCHEMBL16127516 | 0.77 | TTR (0.75) | LRRK2TTRCES1 | |
| Hydrochloric Acid SCHEMBL29530065 | 0.77 | MAPK7 (0.48) | MAPK7DCLK1LRRK2PIK3CDAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379559-B1 | PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS | DANA FARBER CANCER INST INC (US) | 2017-10-25 | — | — | EP | disclosed |
| US-9464091-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20160122357-A1 | PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS | DANA-FARBER CANCER INSTITUTE, INC. | 2016-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122357-A1 | PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS | BRSK2, STK3, BRSK1 | MAPK7 253/4885DCLK1 453/4885LRRK2 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.