Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12190561 | 0.76 | CACNA1I (0.43) | KDM4CKDM4EKDM4AKDM5CKDM4D | |
| SCHEMBL11951648 | 0.75 | KDM4E (0.40) | KDM4CKDM4EKDM4AKDM5CKDM4D | |
| SCHEMBL14664943 | 0.75 | KMT2A (0.42) | — | |
| SCHEMBL28833451 | 0.74 | KDM4C (0.37) | KDM4CKDM4EKDM4AKDM5CKDM4D | |
| Water SCHEMBL28722139 | 0.73 | KMT2A (0.41) | — | |
| SCHEMBL12303239 | 0.73 | NQO1 (0.50) | KDM4CKDM4EKDM4AKDM5CKDM4D | |
| SCHEMBL23489320 | 0.73 | NR1I2 (0.43) | KDM4CKDM4EKDM4AKDM5CKDM4D | |
| SCHEMBL17678791 | 0.72 | MAPK1 (0.30) | — | |
| SCHEMBL798590 | 0.72 | NNMT (0.44) | KDM4E | |
| SCHEMBL11951666 | 0.72 | HPGD (0.41) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327517-A1 | Boronic Acid Inhibitors of HIV Protease | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-11-16 | — | — | US | disclosed |
| US-9738664-B2 | Boronic acid inhibitors of HIV protease | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160122366-A1 | BORONIC ACID INHIBITORS OF HIV PROTEASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122366-A1 | BORONIC ACID INHIBITORS OF HIV PROTEASE | PREP, DNPEP, PEPD | KDM4C 2465/4885KDM4E 2525/4885KDM4A 1603/4885 |
| US-20170327517-A1 | Boronic Acid Inhibitors of HIV Protease | PREP, DNPEP, PEPD | KDM4C 2465/4885KDM4E 2525/4885KDM4A 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.