Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.60 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.59 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.59 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21717780 | 0.93 | PDE4B (0.64) | ERN1SCN5ASCN2ASCN10ANPC1 | |
| SCHEMBL20149733 | 0.92 | PDE4B (0.65) | ERN1NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL4307772 | 0.86 | POLB (0.61) | ERN1NPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL16346225 | 0.83 | HPGD (0.62) | ERN1NPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL12601752 | 0.82 | POLB (0.53) | ERN1NPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL19368310 | 0.82 | CTSC (0.54) | ERN1SCN5ASCN2ASCN10ANPC1 | |
| SCHEMBL700839 | 0.81 | CHKA (0.60) | ERN1NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL25994505 | 0.80 | ALDH1A1 (0.67) | SCN5ASCN2ASCN10ANPC1RAB9A | |
| SCHEMBL18058255 | 0.79 | POLB (0.60) | HPGD | |
| SCHEMBL14549589 | 0.79 | HRH4 (0.60) | ERN1NPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA' DEGLISTUDI DI MILANO- BICOCCA (IT) | 2011-05-12 | — | — | US | claimed |
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA' DEGLISTUDI DI MILANO- BICOCCA (IT) | 2011-05-12 | — | — | US | disclosed |
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA' DEGLISTUDI DI MILANO- BICOCCA (IT) | 2011-05-12 | — | — | US | disclosed |
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA' DEGLISTUDI DI MILANO- BICOCCA (IT) | 2011-05-12 | — | — | US | disclosed |
| WO-2009121535-A2 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA`DEGLI STUDI DI MILANO - BICOCCA (IT) | 2009-10-08 | — | — | WO | disclosed |
| WO-2009121535-A2 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA`DEGLI STUDI DI MILANO - BICOCCA (IT) | 2009-10-08 | — | — | WO | disclosed |
| EP-2107054-A1 | Antiproliferative compounds and therapeutic uses thereof | Università Degli Studi Di Milano - Bicocca (IT) | 2009-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | ABL1, MKI67, BCR | ERN1 1844/4885SCN5A 3575/4885SCN2A 3493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.