Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17723366 | 0.84 | HDAC6 (0.40) | HDAC6CYP2D6KCNH2MEN1KMT2A | |
| SCHEMBL17723386 | 0.84 | HDAC6 (0.40) | HDAC6CYP2D6KCNH2MEN1KMT2A | |
| SCHEMBL17723404 | 0.73 | HDAC6 (0.40) | HDAC6CYP2D6KCNH2MEN1KMT2A | |
| SCHEMBL17723401 | 0.73 | HDAC6 (0.40) | HDAC6CYP2D6KCNH2MEN1KMT2A | |
| SCHEMBL21734119 | 0.72 | ATP1A1 (0.41) | EGFRCRHR1LMNA | |
| SCHEMBL21555165 | 0.72 | ATP1A1 (0.41) | EGFRCRHR1LMNA | |
| SCHEMBL20021995 | 0.71 | EGFR (0.40) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21734154 | 0.71 | PDE2A (0.44) | HDAC6EGFR | |
| SCHEMBL17723859 | 0.71 | PDE2A (0.44) | HDAC6EGFR | |
| SCHEMBL17723357 | 0.70 | ATP1A1 (0.39) | EGFRCRHR1RPS6KB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016070107-A1 | POTENT GAMMA-SECRETASE MODULATORS | THE GENERAL HOSPITAL CORPORATION (US) | 2016-05-06 | — | — | WO | disclosed |