ATP1A1

Sodium/potassium-transporting ATPase subunit alpha-1 · P05023 · ATP1A1 on Sugi Atlas →

17,772 patent compounds predicted against ATP1A1, 10,234 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Metildigoxin (SCHEMBL43349)	0.89	16/20
Digoxin (SCHEMBL20506)	1.00	15/20
Digoxin (SCHEMBL126382)	1.00	15/20
Digoxin (SCHEMBL428012)	1.00	15/20
Digoxin (SCHEMBL597821)	0.94	15/20
Digoxin (SCHEMBL1559560)	0.94	15/20
Digoxin (SCHEMBL1584137)	0.93	15/20
Digoxin (SCHEMBL1461589)	0.58	15/20
SCHEMBL475105	0.51	15/20
SCHEMBL475107	0.51	15/20
Digoxin (SCHEMBL1830809)	0.91	14/20
SCHEMBL1302063	0.85	14/20
SCHEMBL1484406	0.65	14/20
Deslanoside (SCHEMBL125311)	0.80	13/20
Deslanoside (SCHEMBL125312)	0.80	13/20
SCHEMBL1483332	0.74	13/20
SCHEMBL1483335	0.74	13/20
Uzarin (SCHEMBL702463)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL702464)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL1652279)	0.92	12/20

Clinical trials — most relevant to ATP1A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma	PHASE4	COMPLETED
Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes	PHASE4	COMPLETED
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)	PHASE4	UNKNOWN
The Possible Efficacy and Safety of Lansoprazole Co-administration With Neoadjuvant Chemotherapy in Women With Breast Cancer	PHASE3	COMPLETED
Glibentek in Patients With Neonatal Diabetes Secondary to Mutations in K+-ATP Channels	PHASE3	COMPLETED
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)	PHASE2	RECRUITING
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development	nan	COMPLETED
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population	nan	RECRUITING
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients	nan	ACTIVE_NOT_RECRUITING
Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia	nan	ACTIVE_NOT_RECRUITING
Genetic and Environmental Determinants of Hypertension	nan	COMPLETED
Sodium Accumulation Study in Haemodialysis: Brain Study	nan	RECRUITING
Gene Study for Infantile Onset Diabetes	nan	UNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Double Blind Crossover Comparison of Diuretics in the Young	nan	UNKNOWN
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Clinical and Genetic Examinations of Dilated Cardiomyopathy	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Genetic Causes and Clinical Features of Childhood Interstitial Lung Diseases in China	nan	COMPLETED
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS	nan	NOT_YET_RECRUITING
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ATP1A1 binder may also engage these)

Protein	Name	Similarity
Q9N0Z6	—	1.000	Q9N0Z6 →
P04074	—	1.000	P04074 →
Q08DA1	—	1.000	Q08DA1 →
P50997	—	1.000	P50997 →
P06685	—	1.000	P06685 →
Q5RDR3	—	1.000	Q5RDR3 →
P18907	—	1.000	P18907 →
Q92123	—	1.000	Q92123 →
P05024	—	1.000	P05024 →
P25489	—	1.000	P25489 →
Q8VDN2	—	1.000	Q8VDN2 →
P30714	—	1.000	P30714 →
Q9YH26	—	1.000	Q9YH26 →
ATP1A2	Sodium/potassium-transporting ATPase subunit	1.000	landscape →
P09572	—	1.000	P09572 →
P05025	—	1.000	P05025 →
Q92030	—	1.000	Q92030 →
D2WKD8	—	1.000	D2WKD8 →
A2VDL6	—	1.000	A2VDL6 →
Q6PIC6	—	1.000	Q6PIC6 →
P06687	—	1.000	P06687 →
P13607	—	1.000	P13607 →
P24798	—	1.000	P24798 →
P58312	—	1.000	P58312 →
Q6PIE5	—	1.000	Q6PIE5 →
ATP1A3	Sodium/potassium-transporting ATPase subunit	1.000	landscape →
Q5RCD8	—	1.000	Q5RCD8 →
P28774	—	1.000	P28774 →
P06686	—	1.000	P06686 →
P24797	—	1.000	P24797 →