Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KLK7 | P49862 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17728760 | 1.00 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNATRPA1PPARG | |
| SCHEMBL17739822 | 0.89 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNATRPA1PPARG | |
| SCHEMBL17728718 | 0.85 | KLK7 (0.38) | ALDH1A1MAPTKLK7KLK5 | |
| SCHEMBL17728719 | 0.85 | KLK7 (0.38) | ALDH1A1MAPTKLK7KLK5 | |
| SCHEMBL11993549 | 0.83 | KLK7 (0.43) | KLK7KLK5 | |
| SCHEMBL17728737 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNATRPA1NR1D1 | |
| SCHEMBL17728738 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNATRPA1NR1D1 | |
| SCHEMBL17169509 | 0.80 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNATRPA1PPARG | |
| SCHEMBL1150225 | 0.80 | ALDH1A1 (0.52) | ALDH1A1MAPTLMNATRPA1PPARG | |
| SCHEMBL17739821 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNATRPA1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218391-B1 | TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE | BRISTOL MYERS SQUIBB CO (US) | 2019-01-09 | — | — | EP | disclosed |
| US-10077287-B2 | Tubulysin analogs and methods of making and use | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-09-18 | — | — | US | disclosed |
| EP-3218391-A1 | TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE | Bristol-Myers Squibb Company (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077260-A1 | TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-05-19 | — | — | WO | disclosed |
| US-20160130299-A1 | TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE | BRISTOL-MYERS SQUIBB COMPANY | 2016-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130299-A1 | TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE | CCNY, CDC45, TPX2 | ALDH1A1 4730/4885MAPT 2748/4885LMNA 2126/4885 |
| US-10077287-B2 | Tubulysin analogs and methods of making and use | CCNY, CDC45, TPX2 | ALDH1A1 4730/4885MAPT 2748/4885LMNA 2126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.