Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24373105 | 0.77 | IRAK4 (0.72) | IRAK4ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6504605 | 0.75 | USP2 (0.44) | ALDH1A1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL28024114 | 0.73 | POLB (0.73) | IRAK4MTORIRAK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6505871 | 0.73 | PARP1 (0.45) | ALDH1A1MEN1KMT2APOLBLMNA | |
| SCHEMBL3597174 | 0.72 | IRAK4 (1.00) | IRAK4ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25956605 | 0.72 | IRAK4 (0.70) | IRAK4ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3600534 | 0.72 | IRAK4 (1.00) | IRAK4MTORIRAK1KDM4E | |
| SCHEMBL29363239 | 0.72 | IRAK4 (1.00) | IRAK4MTORIRAK1KDM4E | |
| SCHEMBL3604209 | 0.72 | IRAK4 (0.79) | IRAK4MTORIRAK1KDM4E | |
| SCHEMBL175464 | 0.72 | IRAK4 (0.82) | IRAK4MTORIRAK1NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341007-A1 | MALT1 INHIBITORS AND USES THEREOF | Cornell University (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017040304-A1 | MALT1 INHIBITORS AND USES THEREOF | CORNELL UNIVERSITY (US) | 2017-03-09 | — | — | WO | disclosed |
| WO-2016073748-A1 | BIOMARKERS AND TARGETS FOR CANCER IMMUNOTHERAPY | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-05-12 | — | — | WO | disclosed |